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Effect of blood transfusions on cerebral haemodynamics in preterm infants
C Dani1, M Pezzati, E Martelli
1Division of Neonatology, Careggi University Hospital of Florence, Italy. cdani@unifi.it
Aim:
To assess the possible cerebral haemodynamic changes occurring in preterm infants after blood transfusions.
Methods:
Preterm infants who had undergone blood transfusions were prospectively studied using both near infrared spectroscopy and cerebral Doppler ultrasonography.
Results:
Fourteen infants (mean gestational age 29.6 wk, SD 2.6; mean birthweight 1,430g, SD 332) were studied at the mean age of 29 (SD 14) d. A significant increase in oxygenated haemoglobin (O2Hb), deoxygenated haemoglobin (HHb), mixed cerebral oxygen saturation (SmO2) and change in cerebral blood volume occurred after transfusion. Between ultrasound parameters, we found a decrease in diastolic velocity and an increase in resistance index.
Conclusion:
Blood transfusions improve cerebral oxygen supply and induce a decrease in cerebral blood volume, probably due to an increase in cerebral vessel resistance.