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Translational study in cancer research
1Medical Oncology Division, National Cancer Center, Tokyo.
Abstract:
Recent progress in molecular biology has led to the identification of numerous molecular targets of cancer chemotherapy, and the strategies for new drug discovery have concentrated on target-based screening. In the development of target-based drugs, translational research is considered to be essential. In this review, the definition of translational research is clearly explained, and the points of misunderstanding of Japanese researchers are discussed and resolved. The primary goal of translational research is to integrate the advanced informations of molecular biology in moving forward from phase I and II trials to phase III trials of target-based drugs.
Insights
Translational research is essential for advancing target-based cancer drugs from early trials to later phases. This review clarifies its definition and addresses common misunderstandings among researchers.
Area of Science:
- Oncology
- Molecular Biology
- Drug Discovery
Background:
- Molecular biology advancements have identified numerous cancer drug targets.
- Target-based screening is a primary strategy for new cancer drug discovery.
- Translational research is crucial for developing target-based drugs.
Purpose of the Study:
- To clearly define translational research in the context of drug development.
- To address and resolve misunderstandings of translational research among Japanese researchers.
- To emphasize the role of translational research in advancing cancer drug trials.
Main Methods:
- Literature review and conceptual analysis.
- Discussion of translational research principles.
- Analysis of common misconceptions in translational research.
Main Results:
- A clear definition of translational research is provided.
- Specific points of misunderstanding regarding translational research are clarified.
- The integration of molecular biology insights into clinical trials is highlighted.
Conclusions:
- Translational research is key to bridging basic science discoveries with clinical application.
- Accurate understanding of translational research is vital for efficient drug development.
- Effective translational research accelerates the progression of target-based cancer drugs through clinical trials (Phase I, II, and III).