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Alpha-FP normalization as a prognostic factor for mediastinal origin embryonal carcinoma: report of five cases
Yasuko Murakawa1, Nobuaki Satake, Syunsuke Kato
1Department of Clinical Oncology, Institute of Development, Age and Cancer, Tohoku University, Sendai.
Internal Medicine (Tokyo, Japan)
|November 5, 2002
Abstract:
It is well known that a subgroup of germ cell tumors, embryonal carcinoma of extra-gonadal origin have a poor prognosis. We have encountered five cases of mediastinal embryonal carcinoma treated with high-dose chemotherapy (HD-CT) supported by auto-PBSCT in four, and resection in three. Our cases indicated that normalization of the alpha-FP tumor marker level during standard chemotherapy is a very important factor for cure, and the resection of the residual mass after chemotherapy is indicated due to the great risk of remnant malignant cells despite HD-CT.