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Related Experiment Videos

Cardiorespiratory system dynamics in chronic heart failure.

L Mangin1, A Monti, C Médigue

  • 1Service de Pneumologie et Unité de Réanimation, Laboratoire de Physiopathologie Cardio-Respiratoire, UPRES 2397, Pavillon Rambuteau, Groupe Hospitalier Pitié-Salpétrière, 47-83 Bd de l'Hôpital 75013, Paris, France. laurence.mangin@psl.ap-hop-paris.fr

European Journal of Heart Failure
|November 5, 2002
PubMed
Summary

Heart failure patients exhibit a lack of synchronisation between cardiovascular and respiratory signals, indicating a central uncoupling of neuronal activities during breathing. This desynchronization worsens with slower breathing rates.

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Area of Science:

  • Cardiovascular Physiology
  • Respiratory Physiology
  • Neuroscience

Background:

  • Cardiovascular (CV) and respiratory systems exhibit complex interactions.
  • Heart failure (HF) may alter the synchrony between these systems.
  • Understanding this synchrony is crucial for assessing autonomic nervous system function.

Purpose of the Study:

  • To assess instantaneous CV and respiratory oscillations and their phase relationship using complex demodulation (CDM).
  • To investigate the hypothesis of a lack of synchronisation between CV and respiratory signals in chronic heart failure (CHF) patients during paced breathing.
  • To compare synchrony patterns between CHF patients and healthy controls.

Main Methods:

  • Monitored RR interval (ECG), blood pressure, and respiration in 10 CHF patients and 10 controls.

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  • Utilized voluntary paced-breathing at 0.15 Hz and 0.25 Hz.
  • Applied the CDM method to analyze instantaneous amplitude, frequency, and phase (IP) between CV and respiratory oscillations.

    • Main Results:

    • CHF patients showed continuous phase variations between CV and respiratory signals, more pronounced at slower breathing rates (0.15 Hz).
    • Phase variations were significantly greater in CHF patients compared to controls (46+/-57 degrees vs. 6+/-3 degrees at 0.15 Hz, P<0.01).
    • Instantaneous amplitude of high-frequency CV oscillations was more altered in CHF patients, especially at slower breathing rates.

    Conclusions:

    • A lack of synchronisation between physiological signals was observed in CHF patients during voluntary breathing.
    • This desynchronization suggests a central uncoupling between cardiovascular and respiratory neuronal activities in CHF.
    • Findings highlight altered cardiorespiratory coordination in heart failure.