Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement in allergy and asthma.

Norma P Gerard1, Craig Gerard

  • 1Department of Medicine, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Current Opinion in Immunology
|November 5, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Concise Guide to PHARMACOLOGY 2025/26: G protein-coupled receptors.

British journal of pharmacology·2025
Same author

The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors.

British journal of pharmacology·2023
Same author

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors.

British journal of pharmacology·2021
Same author

The oxidation state of cysteine thiols on the ectodomain of TLR2 and TLR4 influences intracellular signaling.

Immunobiology·2019
Same author

CFTR regulates B cell activation and lymphoid follicle development.

Respiratory research·2019
Same author

Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs.

Proceedings of the National Academy of Sciences of the United States of America·2019
Same journal

A blind spot of human T cell immunology: epitope specificity in secondary lymphoid organs.

Current opinion in immunology·2026
Same journal

Germinal center responses at barrier organ sites.

Current opinion in immunology·2026
Same journal

Ocular sarcoidosis: from clinical signs to targeted interventions.

Current opinion in immunology·2026
Same journal

On or within: spatial determinants of antigen handling in the nasal turbinates.

Current opinion in immunology·2026
Same journal

Decoding the complexity of intestinal immunity with spatial transcriptomics.

Current opinion in immunology·2026
Same journal

Reconsidering the immunological aspects of solid-phase assays for antiphospholipid antibodies detection.

Current opinion in immunology·2026
See all related articles

The complement system, crucial for immunity, involves anaphylatoxins C3a and C5a in Type 1 hypersensitivity reactions like asthma. Inhibiting complement may offer new therapeutic strategies for these allergic conditions.

Area of Science:

  • Immunology
  • Allergy Research

Background:

  • The complement system bridges innate and adaptive immunity.
  • Complement anaphylatoxins C3a and C5a are increasingly recognized for their roles beyond pathogen clearance.

Purpose of the Study:

  • To investigate the role of complement anaphylatoxins C3a and C5a in Type 1 hypersensitivity.
  • To explore the potential of complement inhibition as a therapeutic approach for allergic diseases.

Main Methods:

  • Review of recent scientific literature implicating C3a and C5a in allergic responses.
  • Analysis of the synergistic interactions between complement activation and IgE-mediated pathways.

Main Results:

  • Evidence suggests C3a and C5a act as effectors in conditions such as urticaria, rhinitis, and asthma.

Related Experiment Videos

  • Complement activation may enhance classical IgE-mediated allergic reactions.

    • Conclusions:

    • Complement anaphylatoxins are implicated in Type 1 hypersensitivity.
    • Targeting the complement system presents a promising therapeutic avenue for allergic diseases.