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Related Experiment Videos

Immune regulation by histamine.

Marek Jutel1, Takeshi Watanabe, Mübeccel Akdis

  • 1Swiss Institute of Allergy and Asthma Research, Obere Strasse 22, CH-7270 Davos, Switzerland. marek.jutel@siaf.unizh.ch

Current Opinion in Immunology
|November 5, 2002
PubMed
Summary

Histamine, a key bioamine, significantly influences immune responses by modulating dendritic cell maturation and T cell polarization. Its diverse immune regulatory effects stem from differential histamine receptor expression and signaling pathways.

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Area of Science:

  • Immunology
  • Biochemistry
  • Cell Biology

Background:

  • Histamine is a critical bioamine involved in numerous physiological and pathological processes.
  • Beyond its known roles in inflammation and allergy, histamine impacts adaptive immunity.

Purpose of the Study:

  • To elucidate the regulatory roles of histamine in antigen-specific immune responses.
  • To understand how histamine influences immune cell development and function.

Main Methods:

  • The study investigates histamine's effects on dendritic cell maturation.
  • Analysis of histamine's impact on T helper cell differentiation and antibody production.

Main Results:

  • Histamine modulates dendritic cell maturation and their capacity to polarize T cells.

Related Experiment Videos

  • Histamine regulates the development of T helper 1 and T helper 2 cells.
  • Histamine influences specific antibody isotype responses.

    • Conclusions:

    • Histamine plays a multifaceted role in regulating adaptive immunity.
    • Differential expression and signaling of histamine receptors underpin its diverse immune effects.