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In vivo neurochemical monitoring by microdialysis and capillary separations
Robert T Kennedy1, Christopher J Watson, William E Haskins
1Department of Chemistry and Pharmacology, 930 North University, University of Michigan, Ann Arbor 48109-1055, USA. rtkenn@umich.edu
Current Opinion in Chemical Biology
|November 5, 2002
Abstract:
Microdialysis is valuable for studying the neurochemical changes underlying behavior. Recent advances include the application of the high-sensitivity methods of capillary electrophoresis and capillary liquid chromatography with mass spectrometry to dialysate analysis. These methods have improved temporal resolution, spatial resolution, multi-analyte capability and potential for compound discovery.
