[Morphine interaction with reserpine and amphetamine on prolonged administration to rats]

The authors carried out studies on 300 white rats of the Wistar strain and examined the influence of reserpien and amphetamine on creating physical dependence to morphine in rats after sixty days of combined application. Resepine, used continuosty with morphine, hindered the development of tolerance to the analgetic and toxic effect of morphine. However on the background of a three-day administration in rats with reserpine the morphine revealed considerably less toxicity. The amphetamine did not stop the development of the morphine dependence. The amphetamine, administered tere singly for a period of sixty days, created dependence in the rats. The results are discussed in view of the participation of cerebral catecholamines and serotonine in the creotion of morphine dependence.