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Straightforward syntheses of furanomycin derivatives and their biological evaluation
Uli Kazmaier1, Saskia Pähler, Rainer Endermann
1Institut für Organische Chemie, Universität des Saarlandes, Im Stadtwald, Geb. 23.2, 66123 Saarbrücken, Germany. u.kazmaier@mx.uni-sb.de
Bioorganic & Medicinal Chemistry
|November 5, 2002
Abstract:
Several types of furanomycin analogues were synthesized and investigated with respect to their antibacterial activity. Two different synthetic pathways were developed, based on aldol reactions/ring closing metathesis and an ester enolate Claisen rearrangement. Only the natural product and its desmethyl derivative showed antibacterial activity, pointing towards a narrow structure-activity relationship.