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Membrane-permeant derivatives of mannose-1-phosphate
Synke Rutschow1, Joachim Thiem, Christian Kranz
1Institut für Organische Chemie, Universität Hamburg, Martin-Luther-King-Platz 6, Hamburg, Germany.
Bioorganic & Medicinal Chemistry
|November 5, 2002
Abstract:
For treatment of congenital disorder of glycosylation type Ia (CDG-Ia) membrane-permeant derivatives of mannose-1-phosphate are required. Employing biologically cleavable phosphate protecting groups advantageous precursor derivatives could be synthesized following a facile approach. Their enzymatic cleavages using esterase from porcine liver (E.C. 3.1.1.1) were investigated.