Related Experiment Video
Updated: Sep 28, 2026
Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
Published on: August 4, 2021
An analysis of the pattern of pregnancy loss in women with recurrent miscarriage
Tin Chiu Li1, Tanzeem Iqbal, Barbara Anstie
1The Jessop Wing, Sheffield Teaching Hospitals NHS Trust, Sheffield, United Kingdom. tin.li@sth.nhs.uk
Objective:
To describe the pattern of pregnancy loss in women with a history of recurrent miscarriage (RM).
Design:
Retrospective, observational study.
Setting:
A tertiary referral center for RM.
Patient(S):
Five hundred thirty-eight subjects with RM.
Intervention(S):
Women with antiphospholipid syndrome were treated with clexane and aspirin; some patients with uterine anomalies underwent corrective surgery, and some cases of retarded endometrium were treated with hMG.
Main Outcome Measure(S):
Pregnancy outcome, including the stage of pregnancy at which pregnancy loss occurred.
Result(S):
In women with a prothrombotic state, the miscarriage rate before the detection of fetal heart activity (early loss) in the untreated group (50%) was significantly higher than in the treatment group (17.5%). In women with a uterine anomaly, the early loss rate and the later loss rate (after detection of fetal heart activity) were both increased. Women with retarded endometrium, women with >/=6 losses, and older women (>/=41 years) are more likely to have a further early loss but not a later loss.
Conclusion(S):
An understanding of the patterns of pregnancy loss provides further insight into the mechanism of the reproductive failure, which has implications for treatment.
Related Concept Videos
01:52Regression Toward the Mean
01:27Ovarian Cycle