Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Visual object working memory function and clinical symptoms in schizophrenia.

Sohee Park1, Jörg Püschel, Barbara H Sauter

  • 1Department of Psychology, Vanderbilt University, Wilson Hall, 111 21st Ave South, 37Nashville, TN 37240-0009, USA. sohee.park@vanderbilt.edu

Schizophrenia Research
|November 5, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical Features in Patients With Early-Onset Colorectal Cancer: An Evaluation of Data From the StuDoQ Database.

Deutsches Arzteblatt international·2025
Same author

Excellent efficacy and beneficial safety during observational 5-year follow-up of rapid steroid withdrawal after renal transplantation (Harmony FU study).

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2023
Same author

Association of polypharmacy with all-cause mortality and adverse events among elderly colorectal cancer survivors.

Cancer·2023
Same author

Prediction Models for Mediastinal Metastasis and Its Detection by Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in Potentially Operable Non-Small Cell Lung Cancer: A Prospective Study.

Chest·2023
Same author

The felt-presence experience: from cognition to the clinic.

The lancet. Psychiatry·2023
Same author

Recurrence Patterns and Patient Outcomes in Resected Lung Adenocarcinoma Differ according to Ground-Glass Opacity at CT.

Radiology·2023
Same journal

Initiation patterns of long-acting injectable antipsychotics in a claims-based proxy cohort approximating first-episode schizophrenia: A longitudinal descriptive study using a Japanese claims database.

Schizophrenia research·2026
Same journal

Identifying in-the-moment alterations in socioemotional connection in youth at clinical high risk for psychosis and their caregivers via positivity resonance.

Schizophrenia research·2026
Same journal

Positive affect during social interactions predicts goal progress and social motivation in daily life for people with schizophrenia.

Schizophrenia research·2026
Same journal

Quality evaluation of randomized controlled trials of antipsychotic drugs for schizophrenia published in Chinese journals.

Schizophrenia research·2026
Same journal

FL-SDGIN: A federated graph learning approach for schizophrenia diagnosis integrating static and dynamic brain functional networks.

Schizophrenia research·2026
Same journal

Weight loss and gut microbial changes associated with semaglutide among people living with schizophrenia receiving clozapine or olanzapine: An open-label 24-week semaglutide intervention and 76-week trial.

Schizophrenia research·2026
See all related articles

Schizophrenia patients show persistent object working memory deficits, particularly with novel shapes, even during remission. These impairments are linked to negative symptoms, suggesting a specific cognitive challenge in schizophrenia.

Area of Science:

  • Cognitive Neuroscience
  • Psychiatry
  • Neuroimaging

Background:

  • Working memory deficits are common in schizophrenia, often linked to prefrontal cortex (PFC) dysfunction.
  • While spatial working memory is well-studied in schizophrenia, object working memory deficits remain less understood.
  • Understanding object working memory is crucial for characterizing the full spectrum of cognitive impairments in schizophrenia.

Purpose of the Study:

  • To investigate nonspatial, object working memory function in schizophrenia patients.
  • To examine the relationship between object working memory performance and clinical symptoms.
  • To assess changes in object working memory over time, from acute psychosis to partial remission.

Main Methods:

  • Object working memory was assessed using delayed-matching-to-sample tasks for familiar objects (DMTS-F) and novel shapes (DMTS-N).

Related Experiment Videos

  • 28 schizophrenia patients were evaluated during acute psychosis and 4 months later during partial remission.
  • Clinical symptoms were measured using the Positive and Negative Syndrome Scale (PANSS); 33 healthy controls were also studied.

    • Main Results:

    • Schizophrenia patients exhibited deficits in both DMTS-F and DMTS-N during acute psychosis.
    • After 4 months, DMTS-F performance improved, but DMTS-N deficits persisted.
    • During acute psychosis, symptoms correlated with DMTS-F; in partial remission, negative symptoms correlated with both tasks.

    Conclusions:

    • Object working memory, especially for novel shapes (DMTS-N), is impaired in schizophrenia across acute and remitted states.
    • Persistent deficits in novel object working memory suggest a core cognitive abnormality in schizophrenia.
    • Object working memory performance in partial remission is associated with negative symptoms, highlighting a potential therapeutic target.