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The meaning of it all: web-based resources for large-scale functional annotation and visualization of DNA microarray
Alessandro Guffanti1, James F Reid, Myriam Alcalay
1IFOM-FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milano, Italy. guffanti@ifom-firc.it
Trends in Genetics : TIG
|November 5, 2002
Summary
Genome projects generate vast unstructured data, prompting the creation of web tools for gene annotation. This review evaluates several tools based on their scope, limitations, and usability for biological information.
Area of Science:
- Genomics
- Bioinformatics
- Computational Biology
Background:
- The rapid expansion of genome sequencing projects generates massive amounts of unstructured biological data.
- Efficiently annotating genes with relevant biological information is crucial for understanding biological functions and pathways.
Purpose of the Study:
- To review and compare various web-based tools developed for gene annotation.
- To assess the scope, limitations, and ease of use of selected gene annotation tools.
Main Methods:
- Literature search for relevant web-based gene annotation tools.
- Comparative analysis of identified tools based on predefined criteria (scope, limitations, usability).
Main Results:
- A selection of gene annotation tools were identified and analyzed.
- Key differences in the scope of biological information covered by each tool were highlighted.
- Limitations and user-friendliness of the discussed tools were evaluated.
Conclusions:
- Web-based tools offer valuable solutions for annotating gene data from genome projects.
- Understanding the specific scope, limitations, and usability is essential for selecting the appropriate tool for gene annotation tasks.