Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lymphoma-associated retinopathy.

King W To1, Charles E Thirkill, Frederick A Jakobiec

  • 1Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA.

Ophthalmology
|November 5, 2002
PubMed
Summary

This study details a patient with progressive paraneoplastic retinopathy linked to Hodgkin's lymphoma. Researchers identified serum antibodies targeting retinal proteins, suggesting an autoimmune cause for vision loss.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Histopathology of Hydrolyzed MIRAgel Scleral Buckles.

Ocular oncology and pathology·2021
Same author

Conjunctival Actinic Granuloma: A Clinicopathological and Immunohistochemical Study With a Review of the Literature and a Differential Diagnosis.

Ophthalmic plastic and reconstructive surgery·2021
Same author

Epibulbar Proliferative Fasciitis, a Variant of Nodular Fasciitis: A Differential Diagnosis of Conditions With Focal or Diffuse Myxoid Stromas.

Ophthalmic plastic and reconstructive surgery·2021
Same author

Lacrimal Gland Intravascular Micrometastasis From a Human Papillomavirus-Driven Anorectal Squamous Cell Carcinoma With a Review of Metastatic Disease to the Lacrimal Gland.

Ophthalmic plastic and reconstructive surgery·2020
Same author

Multicameral Steatocystoma Simplex of the Caruncle.

Ophthalmic plastic and reconstructive surgery·2020
Same author

Relationship between Conjunctival Intraepithelial Dendritic Melanocytes and Nevocytes.

Ocular oncology and pathology·2020

Area of Science:

  • Ophthalmology
  • Oncology
  • Immunology

Background:

  • Hodgkin's lymphoma is a cancer of the lymphatic system.
  • Paraneoplastic syndromes can affect various organs, including the eyes.

Observation:

  • A 24-year-old woman developed night blindness and fundus abnormalities during chemotherapy for Hodgkin's lymphoma.
  • Clinical monitoring over 10 years showed progressive visual field loss and reduced electroretinogram (ERG) amplitudes.

Findings:

  • Serum analysis revealed antibodies reacting to a ~65 kDa retinal protein.
  • These antibodies demonstrated immunologic activity against photoreceptor cells.

Implications:

  • This case suggests a paraneoplastic retinopathy associated with Hodgkin's lymphoma.

Related Experiment Videos

  • The findings implicate a specific antibody-mediated autoimmune response against retinal proteins in the pathogenesis.