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Dichotomal effect of the coumadin derivative warfarin on inflammatory signal transduction
Arnon P Kater1, Maikel P Peppelenbosch, Dees P M Brandjes
1Laboratory for Experimental Internal Medicine, Academic Medical Centre, 1105 AZ Amsterdam, The Netherlands.
Clinical and Diagnostic Laboratory Immunology
|November 5, 2002
Abstract:
Warfarin, a widely prescribed drug for preventing thrombosis, is thought to act solely through inhibition of vitamin K-dependent coagulation factors. Low concentrations of warfarin inhibit interleukin-6 production and phosphorylation of I-kappa B but not activation of p38 mitogen-activated protein kinase. Thus, warfarin inhibits inflammatory signal transduction, and this may contribute to clinical effects of warfarin.