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Updated: Sep 28, 2026

Detection of Abnormal Prion Protein by Immunohistochemistry
Published on: May 5, 2023
Comparison of abnormal prion protein glycoform patterns from transmissible spongiform encephalopathy agent-infected
Richard E Race1, Anne Raines, Thierry G M Baron
1Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA.
Abstract:
Analysis of abnormal prion protein glycoform patterns from chronic wasting disease (CWD)-affected deer and elk, scrapie-affected sheep and cattle, and cattle with bovine spongiform encephalopathy failed to identify patterns capable of reliably distinguishing these transmissible spongiform encephalopathy diseases. However, PrP-res patterns sometimes differed among individual animals, suggesting infection by different or multiple CWD strains in some species.
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