Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intraflagellar transport.

Joel L Rosenbaum1, George B Witman

  • 1Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA.

Nature Reviews. Molecular Cell Biology
|November 5, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Activation of the ciliary kinase CDKL5 is mediated by the cyclin-dependent kinase CDK20/LF2 to control flagellar length.

PLoS biology·2025
Same author

Distribution and bulk flow analyses of the intraflagellar transport (IFT) motor kinesin-2 support an "on-demand" model for Chlamydomonas ciliary length control.

Cytoskeleton (Hoboken, N.J.)·2024
Same author

Direct in situ protein tagging in Chlamydomonas reinhardtii utilizing TIM, a method for CRISPR/Cas9-based targeted insertional mutagenesis.

PloS one·2022
Same author

Tribute to Sidney Altman.

RNA (New York, N.Y.)·2022
Same author

Consensus nomenclature for dyneins and associated assembly factors.

The Journal of cell biology·2022
Same author

Structural organization of the C1b projection within the ciliary central apparatus.

Journal of cell science·2021
Same journal

Human aminoacyl-tRNA synthetases as integrators of translation and cell signalling networks.

Nature reviews. Molecular cell biology·2026
Same journal

How proteins fold.

Nature reviews. Molecular cell biology·2026
Same journal

Single-cell evidence for PANoptosome complexes.

Nature reviews. Molecular cell biology·2026
Same journal

Reply to 'Single-cell evidence for PANoptosome complexes'.

Nature reviews. Molecular cell biology·2026
Same journal

Plucking cellular ribosomes with Ribo-Tweezer.

Nature reviews. Molecular cell biology·2026
Same journal

COPII meets autophagy at the ER membrane.

Nature reviews. Molecular cell biology·2026
See all related articles

Intraflagellar transport (IFT) is essential for building and maintaining eukaryotic cilia and flagella. Disruptions in this vital transport system may underlie certain human diseases.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • Eukaryotic cilia and flagella are critical organelles involved in cell motility and sensory functions.
  • These structures are found on a wide range of cell types, highlighting their conserved importance.
  • Their assembly and function rely on a complex intracellular transport mechanism.

Purpose of the Study:

  • To elucidate the fundamental role of intraflagellar transport (IFT) in the assembly and maintenance of cilia and flagella.
  • To investigate the potential link between IFT defects and human pathologies.

Main Methods:

  • The study focuses on the mechanism of intraflagellar transport (IFT).
  • It examines the movement of particles within cilia and flagella.
  • The research reviews existing data on IFT and its implications.

Related Experiment Videos

Main Results:

  • Intraflagellar transport (IFT) is identified as the key system for moving particles essential for cilia and flagella construction and upkeep.
  • IFT facilitates bidirectional movement of components from the cell body to the organelle tip and back.
  • Emerging evidence suggests IFT dysfunction is implicated in human disease.

Conclusions:

  • Intraflagellar transport (IFT) is indispensable for the structural integrity and functional competence of eukaryotic cilia and flagella.
  • Defects in IFT represent a significant etiological factor in various human diseases.
  • Further research into IFT mechanisms could reveal novel therapeutic targets.