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Opinion: Interpretation of the complexity of innate immune responses by functional genomics
Paola Ricciardi-Castagnoli1, Francesca Granucci
1Department of Biotechnology and Bioscience, University of Milano-Bicocca, Piazza della Scienza 2, Milan, Italy. paola.castgnoli@unimib.it
Nature Reviews. Immunology
|November 5, 2002
Abstract:
Understanding how the immune system is regulated and responds to pathogens will require whole-system approaches, because the study of single immunological parameters has, so far, been unable to unlock immune-system complexity. Global transcription analysis using microarray technologies provides a new approach to the description of complex biological phenomena. Here, we discuss insights into innate immunity that have been provided by genome-wide approaches and their impact on the interpretation of immune-system complexity.