Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effect of atropine on behavioral arousal in the developing rat.

D Blozovski, J Bachevalier

    Developmental Psychobiology
    |March 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effects of Social Status on Reproductive Success, Physiology and Maternal Care in Socially housed Female Rhesus Macaques.

    bioRxiv : the preprint server for biology·2025
    Same author

    The effects of chronic social stress on cognitive flexibility in adult female macaques.

    bioRxiv : the preprint server for biology·2025
    Same author

    Structural Effects of Low Social Status and Obesogenic Diet on Social and Emotional Neurocircuits in Female Macaques: A Longitudinal Study from Infancy to Adulthood.

    bioRxiv : the preprint server for biology·2025
    Same author

    The role of puberty on physical and brain development: A longitudinal study in male Rhesus Macaques.

    Developmental cognitive neuroscience·2023
    Same author

    Validation of the Social Responsiveness Scale (SRS) to screen for atypical social behaviors in juvenile macaques.

    PloS one·2021
    Same author

    Structural development of cortical lobes during the first 6 months of life in infant macaques.

    Developmental cognitive neuroscience·2021
    Same journal

    Maternal Early Pregnancy Tetrahydrocannabinol (THC) Metabolites Correlate With Newborn Resting-State Functional Connectivity.

    Developmental psychobiology·2026
    Same journal

    Navigating Stress: Exploring the Role of Empathy in Caregiving.

    Developmental psychobiology·2026
    Same journal

    Children With Idiopathic Toe Walking Display Different Cortical Activation Patterns When Interpreting Tactile Sensation.

    Developmental psychobiology·2026
    Same journal

    Epigenetic Mechanisms Linking Maternal Stress During Pregnancy to Autism Spectrum Disorders: A Narrative Review.

    Developmental psychobiology·2026
    Same journal

    Quantifying Visuomotor Maturation From Middle Childhood to Adolescence.

    Developmental psychobiology·2026
    Same journal

    Activational Effects of Gonadal Hormones on Social Reward Motivation in Adolescence and Adulthood in Female and Male Long-Evans Rats.

    Developmental psychobiology·2026
    See all related articles

    Atropine significantly altered behavioral arousal in developing rats. A cholinergic inhibitory mechanism controlling arousal matures after 25 days of age in rats.

    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Pharmacology

    Background:

    • Cholinergic systems play a crucial role in regulating behavioral arousal.
    • Understanding the developmental trajectory of these systems is vital for comprehending neurodevelopmental processes.

    Purpose of the Study:

    • To investigate the effects of atropine, a muscarinic antagonist, on behavioral arousal in developing rats.
    • To determine the age at which cholinergic mechanisms controlling arousal become functional.

    Main Methods:

    • Rats aged 21–40 days were administered atropine (10 mg/kg, i.p.).
    • Behavioral arousal was assessed using spontaneous activity measures on an elevated T-maze, including errors, rearing, and stereotyped responses.

    Main Results:

    Related Experiment Videos

    • Atropine decreased spontaneous activity in rats younger than 25 days.
    • Behavioral arousal significantly increased between 26 and 30 days, peaking on day 28.
    • The effects of atropine were minimal in rats older than 30 days.

    Conclusions:

    • The findings suggest a developing cholinergic inhibitory mechanism that regulates behavioral arousal.
    • This mechanism appears to mature and become efficient after the 25th day of life in rats.