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Gastroschisis: a 15-year, single-center experience
Amulya K Saxena1, Georg Hülskamp, Jürgen Schleef
1Pediatric Surgical Clinic, Westfälische Wilhelms University, Albert-Schweitzer-Strasse 33, 48129 Münster, Germany. saxena@post.com
Pediatric Surgery International
|November 5, 2002
Summary
Solvent-dried dura (SDD) grafts are effective for repairing large gastroschisis (GS) defects in infants. This study found SDD implants to be a safe and acceptable biomaterial with minimal complications, supporting their use in complex GS cases.
Area of Science:
- Pediatric Surgery
- Neonatal Care
- Biomaterials Science
Background:
- Gastroschisis (GS) is a congenital abdominal wall defect requiring surgical intervention.
- Management of large GS defects presents challenges in achieving primary closure.
- Solvent-dried dura (SDD) is a potential biomaterial for abdominal wall reconstruction.
Purpose of the Study:
- To evaluate the efficacy and safety of solvent-dried dura (SDD) grafts for surgical repair of gastroschisis (GS).
- To assess complications and outcomes associated with SDD graft use in GS patients.
Main Methods:
- Retrospective analysis of 70 gastroschisis cases surgically treated between 1984 and 1998.
- Surgical repair techniques included primary closure, single SDD graft, and double SDD graft for fascial enlargement.
- Data collected on patient demographics, delivery methods, associated anomalies, surgical outcomes, and complications.
Main Results:
- 41 infants (58.6%) required two SDD grafts for closure of extensive defects.
- Associated anomalies were present in 31.4% of patients, most commonly bowel atresias.
- Overall mortality was 2.8%; no major complications were linked to SDD implants, with only 5.7% experiencing minor issues.
Conclusions:
- Solvent-dried dura (SDD) implants are an acceptable and safe biomaterial for repairing large gastroschisis defects.
- SDD grafts facilitate successful closure in complex cases, demonstrating a low rate of significant complications.
- The findings support the continued use of SDD grafts in the management of challenging gastroschisis cases.