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Updated: Sep 28, 2026

A Common Marmoset Model of Mother-Infant Intervention for Breastfeeding Disorders in the Presence of Paternal Inhibition and Maternal Neglect
Published on: September 22, 2023
Serum bupropion levels in 2 breastfeeding mother-infant pairs
Susan W Baab1, Kathleen S Peindl, Catherine M Piontek
1Frances Payne Bolton School of Nursing, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA.
Background:
These are the first reported data on bupropion and hydroxybupropion levels in infants whose treated mothers were breastfeeding. The information will assist physicians and parents in the risk-benefit decision-making process for bupropion treatment during breastfeeding.
Method:
Serum samples were obtained by venipuncture from 2 mother-infant pairs. The serum was assayed for levels of bupropion and its most active metabolite, hydroxybupropion.
Results:
Neither infant had quantifiable serum levels of bupropion or its metabolite at steady state. Neither infant had medical problems during the time of maternal therapy.
Conclusion:
We recommend obtaining and publishing additional serum level findings for breastfeeding mother-infant pairs since data for bupropion are favorable but limited.
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