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Updated: Sep 28, 2026

Time-Resolved In Vivo Measurement of Neuropeptide Dynamics by Capacitive Immunoprobe in Porcine Heart
Published on: May 19, 2022
Neuropeptide Y and its receptors as potential therapeutic drug targets
Antonio P Silva1, Claudia Cavadas, Eric Grouzmann
1Division of Hypertension and Vascular Medicine, Centre Hospitalier Universitaire Vaudois, Av. Pierre Decker, 1011 Lausanne, Switzerland.
Abstract:
Neuropeptide Y (NPY) is a 36-amino-acid peptide that exhibits a large number of physiological activities in the central and peripheral nervous systems. NPY mediates its effects through the activation of six G-protein-coupled receptor subtypes named Y(1), Y(2), Y(3), Y(4), Y(5), and y(6). Evidence suggests that NPY is involved in the pathophysiology of several disorders, such as the control of food intake, metabolic disorders, anxiety, seizures, memory, circadian rhythm, drug addiction, pain, cardiovascular diseases, rhinitis, and endothelial cell dysfunctions. The synthesis of agonists and antagonists for these receptors could be useful to treat several of these diseases.
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