Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

PSF and p54(nrb)/NonO--multi-functional nuclear proteins.

Yaron Shav-Tal1, Dov Zipori

  • 1Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel.

FEBS Letters
|November 6, 2002
PubMed
Summary

Nuclear factors polypyrimidine tract-binding protein-associated splicing factor (PSF) and p54(nrb)/NonO are multi-functional proteins. These nuclear factors participate in various nuclear processes beyond their initially identified roles in splicing and transcription.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nuclear speckles are regulatory hubs for viral and host mRNA expression during HSV-1 infection.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Targeting bladder cancer: Potent anti-cancer effects of cannabichromene and delta-9-tetrahydrocannabinol-rich <i>Cannabis sativa</i> strains.

Asian journal of urology·2025
Same author

Functional investigation of the RNA helicase MOV10 with respect to its interplay with factors involved in nonsense-mediated mRNA decay.

The Journal of biological chemistry·2025
Same author

Glutamine modulates stress granule formation in cancer cells through core RNA-binding proteins.

Journal of cell science·2025
Same author

HLH-30/TFEB Rewires the Chaperone Network to Promote Proteostasis Upon Perturbations to the Coenzyme A and Iron-Sulfur Cluster Biosynthesis Pathways.

Aging cell·2025
Same author

HLH-30/TFEB rewires the chaperone network to promote proteostasis under conditions of Coenzyme A and Iron-Sulfur Cluster Deficiency.

bioRxiv : the preprint server for biology·2024

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Proteins are often named after their initial discovery context, leading to limited functional categorization.
  • Nuclear factors can participate in multiple simultaneous molecular reactions within the nucleus.
  • Polypyrimidine tract-binding protein-associated splicing factor (PSF) was initially linked to pre-mRNA splicing.
  • p54(nrb)/NonO was initially associated with transcriptional regulation.

Purpose of the Study:

  • To review the diverse functions of nuclear factors PSF and p54(nrb)/NonO.
  • To challenge the simplistic categorization of these proteins based on initial discoveries.
  • To highlight the multi-functional nature of PSF and p54(nrb)/NonO in nuclear processes.

Main Methods:

Related Experiment Videos

  • Literature review of recent evidence on PSF and p54(nrb)/NonO functions.
  • Analysis of studies demonstrating involvement in various nuclear activities.
  • Synthesis of findings to illustrate protein multifunctionality.

Main Results:

  • PSF and p54(nrb)/NonO are not confined to single functions like splicing or transcription.
  • These proteins exhibit complex roles in multiple nuclear processes.
  • Evidence indicates a broader involvement in cellular molecular machinery.

Conclusions:

  • The functional categorization of PSF and p54(nrb)/NonO requires re-evaluation.
  • These nuclear factors possess multi-functional characteristics.
  • Understanding their diverse roles is crucial for comprehending nuclear regulation.