Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intracellular glycosylation and development.

Niall O'Donnell1

  • 1Department of Cellular and Molecular Medicine, The Howard Hughes Medical Institute, Glycobiology Research and Training Center, University of California San Diego, La Jolla 92093, USA.

Biochimica Et Biophysica Acta
|November 6, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immune or at-risk? Stock markets and the significance of the COVID-19 pandemic.

Journal of behavioral and experimental finance·2021
Same author

Visual loss.

The British journal of general practice : the journal of the Royal College of General Practitioners·2010
Same author

Periocular dermatitis artefacta in a child.

Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus·2006
Same author

The histamine H4 receptor mediates allergic airway inflammation by regulating the activation of CD4+ T cells.

Journal of immunology (Baltimore, Md. : 1950)·2006
Same author

Evidence for persistence of adenovirus in the tear film a decade following conjunctivitis.

Journal of medical virology·2005
Same author

Dynamic O-GlcNAc modification of nucleocytoplasmic proteins in response to stress. A survival response of mammalian cells.

The Journal of biological chemistry·2004

O-linked N-acetylglucosamine (O-GlcNAc) is a key protein modification. This review explores its interplay with phosphorylation, impacting cellular functions and development.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cellular Biology

Background:

  • O-linked N-acetylglucosamine (O-GlcNAc) is a prevalent post-translational modification in cytoplasmic and nuclear proteins.
  • All O-GlcNAc-modified proteins are also phosphoproteins, with modification sites often overlapping or adjacent to phosphorylation sites.

Purpose of the Study:

  • To review the functions of O-GlcNAc-modified proteins.
  • To explore the potential regulatory role of O-GlcNAc modification in protein function.
  • To predict the impact of altered O-GlcNAc levels on cellular processes and development.

Main Methods:

  • Literature review of O-GlcNAc-modified proteins and their functions.
  • Analysis of the relationship between O-GlcNAc and protein phosphorylation.

Related Experiment Videos

  • Predictive modeling of cellular and developmental consequences of O-GlcNAc level changes.

    • Main Results:

    • O-GlcNAc modification is intricately linked with protein phosphorylation.
    • Evidence suggests a dynamic interplay between O-GlcNAc and phosphorylation in regulating protein activity.
    • Specific examples of O-GlcNAc protein functions are discussed in relation to this interplay.

    Conclusions:

    • The dynamic interplay between O-GlcNAc and phosphorylation is crucial for regulating protein function.
    • Changes in O-GlcNAc levels likely have significant implications for cellular function and developmental regulation.
    • Further research is warranted to fully elucidate the roles of O-GlcNAc in biological systems.