Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Social stress alters splenocyte phenotype and function.

Ronit Avitsur1, Jennifer L Stark, Firdaus S Dhabhar

  • 1Section of Oral Biology, The Ohio State University Health Sciences Center, Columbus, OH, USA.

Journal of Neuroimmunology
|November 6, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Peritraumatic C-reactive protein levels predict pain outcomes following traumatic stress exposure in a sex-dependent manner.

The journal of pain·2026
Same author

Associations between residential segregation, ambient air pollution, and hippocampal features in recent trauma survivors.

Translational psychiatry·2026
Same author

Masculine Identity, Body Image and Illness-Related Shame: Pathways to Psychological Distress in Men with Fibromyalgia.

Healthcare (Basel, Switzerland)·2026
Same author

Traumatic brain injury and post-injury sleep fragmentation differentially alter the microglial transcriptome.

Frontiers in immunology·2026
Same author

Associations Between Micronutrient Status, Hormones, and Immune Status During Pregnancy and Child Growth in Rural Bangladesh: A Prospective Cohort Study.

Current developments in nutrition·2025
Same author

Defining the <i>r</i> factor for post-trauma resilience and its neural predictors.

Nature. Mental health·2025

Social stress from fighting in mice causes immune cells in the spleen to change. This stress leads to glucocorticoid (GC) resistance in these cells, impacting immune function.

Area of Science:

  • Immunology
  • Neuroendocrinology
  • Stress Physiology

Background:

  • Social stress is a significant factor affecting immune responses.
  • Glucocorticoids (GCs) are key regulators of the immune system.
  • Understanding stress-induced immune alterations is crucial for health implications.

Purpose of the Study:

  • To investigate the impact of paired-fighting (PF) social stress on splenic immune cell distribution and function in male mice.
  • To determine if PF stress induces glucocorticoid (GC) resistance in splenocytes.

Main Methods:

  • Male mice were subjected to daily paired-fighting (PF) stress sessions.
  • Immune cell populations in the spleen were analyzed using flow cytometry.
  • Splenocyte proliferation and sensitivity to corticosterone were assessed in response to lipopolysaccharide (LPS) stimulation.

Related Experiment Videos

Main Results:

  • PF stress led to an increase in splenic monocytes and neutrophils, with a decrease in lymphocytes.
  • Alterations in the distribution of CD62L and CD11b positive monocytes were observed.
  • PF stress enhanced splenocyte proliferation and induced resistance to the antiproliferative effects of corticosterone.

Conclusions:

  • Social stress through paired fighting significantly alters the phenotype and function of splenic immune cells in male mice.
  • These stress-induced changes include the development of functional glucocorticoid (GC) resistance in splenocytes.
  • Findings suggest potential implications for wound healing in contexts of social stress and injury.