Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decoupling eye-specific segregation from lamination in the lateral geniculate nucleus.

Andrew D Huberman1, David Stellwagen, Barbara Chapman

  • 1Center for Neuroscience, University of California, Davis, California 95616, USA.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|November 6, 2002
PubMed
Summary

A critical period exists for developing eye-specific layers in the lateral geniculate nucleus (LGN). Disrupting afferent segregation during this period prevents normal lamination, leading to disorganized inputs despite restored eye-specific territories.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transregional astrocyte-dependent metaplasticity in the hippocampus.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Virtual reality stimulation for neuroprotection and neuroenhancement of vision in optic neuropathy patients: a prospective clinical trial.

BMC ophthalmology·2025
Same author

A screen of immune signaling molecules regulated by neuronal activity identifies interferon-gamma as a modulator of synaptic function and anxiety-like behavior.

Brain, behavior, and immunity·2025
Same author

ABHD6 loss-of-function in mesoaccumbens postsynaptic but not presynaptic neurons prevents diet-induced obesity in male mice.

Nature communications·2024
Same author

Neurotoxic Reactive Astrocytes Drive Neuronal Death after Retinal Injury.

Cell reports·2024
Same author

Astrocytes Are the Source of TNF Mediating Homeostatic Synaptic Plasticity.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2024

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Visual System Research

Background:

  • The development of eye-specific layers in the lateral geniculate nucleus (LGN) is crucial for visual processing.
  • Understanding the critical periods governing this layered structure is essential for comprehending visual system development.

Purpose of the Study:

  • To investigate if a critical developmental period exists for the formation of eye-specific layers in the LGN.
  • To determine the consequences of disrupting afferent segregation during this period on LGN lamination and function.

Main Methods:

  • Retinogeniculate afferents were experimentally manipulated to prevent normal segregation.
  • An extended recovery period was allowed before anatomical and physiological assessments.
  • LGN structure, afferent organization, and cellular responses were analyzed.
Keywords:
Non-programmatic

Related Experiment Videos

Main Results:

  • Despite recovery, eye-specific afferent territories remained segregated but developed as disorganized patches, lacking normal interlaminar spaces.
  • The normal stereotyped pattern of eye-specific afferent and cellular layers failed to develop.
  • Physiological assessments showed normal single-cell responses and topographic mapping, but disrupted ON and OFF sublamina organization.

Conclusions:

  • A critical period is necessary for coordinating LGN afferent segregation, spatial lamination, and postsynaptic cytoarchitecture alignment.
  • Disruption during this period leads to abnormal LGN lamination, impacting visual pathway development.
  • While basic visual processing and cell segregation are resilient, precise laminar organization is critically dependent on early developmental timing.