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[Peripheral muscle dysfunction in chronic obstructive pulmonary disease].

F Maltais¹, P Leblanc, J Jobin

¹Institut universitaire de cardiologie et de pneumologie, Hôpital Laval, Université Laval, Québec, Canada.

Revue Des Maladies Respiratoires

|November 6, 2002

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Patients with chronic obstructive pulmonary disease (COPD) experience peripheral muscle dysfunction, leading to weakness and reduced exercise capacity. This review discusses the implications and therapeutic strategies for improving muscle function in COPD patients.

Area of Science:

Pulmonary Medicine
Exercise Physiology
Muscle Biology

Context:

Chronic obstructive pulmonary disease (COPD) frequently causes systemic complications beyond lung impairment.
Peripheral muscle dysfunction, marked by atrophy, weakness, and reduced oxidative capacity, is a significant complication in COPD patients.
These muscle alterations impact exercise tolerance and quality of life independently of respiratory function.

Purpose:

To review the evidence supporting peripheral muscle dysfunction in COPD.
To discuss the clinical implications of muscle dysfunction in COPD.
To examine current therapeutic options for enhancing peripheral muscle function in COPD.

Summary:

Peripheral muscle dysfunction is a common systemic complication in COPD, characterized by atrophy, weakness, and low oxidative capacity.

Related Experiment Videos

These changes significantly affect exercise tolerance and quality of life, irrespective of lung function.

The article explores the evidence, clinical relevance, and treatment strategies for this condition.

Impact:

Highlights the importance of addressing peripheral muscle dysfunction in COPD management.
Informs clinicians about the systemic effects of COPD on skeletal muscles.
Provides an overview of potential interventions to improve muscle health and patient outcomes in COPD.