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Related Experiment Videos

Multiple gradient echo sequence optimized for rapid, single-scan mapping of R(2)(*) at high B0.

Jim M Wild1, W R Wayne Martin, Peter S Allen

  • 1Department of Biomedical Engineering, University of Alberta, Edmonton, Canada. j.m.wild@sheffield.ac.uk

Magnetic Resonance in Medicine
|November 6, 2002
PubMed
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This study introduces a novel multiple-gradient-echo sequence to accurately map R(2)(*) values. The method effectively reduces signal loss from magnetic susceptibility gradients, improving R(2)(*) mapping accuracy.

Area of Science:

  • Magnetic Resonance Imaging
  • Biophysics
  • Medical Physics

Background:

  • Accurate R(2)(*) mapping is crucial for understanding microscopic magnetic field inhomogeneities.
  • Macroscopic susceptibility gradients in MRI can cause significant signal loss and inaccurate R(2)(*) measurements.
  • Existing methods struggle to compensate for in-slice susceptibility variations.

Purpose of the Study:

  • To develop and validate a novel multiple-gradient-echo (MGE) sequence for precise R(2)(*) mapping.
  • To mitigate signal loss caused by in-slice macroscopic susceptibility gradients.
  • To enable single-scan acquisition of artifact-compensated R(2)(*) maps.

Main Methods:

  • A novel MGE sequence using successively incremented slice-refocusing gradients was designed.

Related Experiment Videos

  • Numerical simulations were performed to optimize gradient incrementation.
  • The sequence was tested at 3.0T using a doped aqueous phantom and a human volunteer.
  • Quantitative comparison with previously published methods was conducted.

    • Main Results:

    • The proposed MGE sequence successfully mitigated in-slice signal loss due to macroscopic susceptibility gradients.
    • Artifact-compensated data across a range of echo times (TEs) were acquired in a single scan.
    • Quantitative R(2)(*) maps reflecting microscopic field inhomogeneities were generated.
    • Demonstrated performance at 3.0T in both phantom and in-vivo brain imaging.

    Conclusions:

    • The novel MGE sequence provides accurate R(2)(*) mapping in the presence of challenging susceptibility gradients.
    • This technique offers a robust solution for quantitative assessment of microscopic magnetic field variations.
    • The method holds promise for improved MRI-based studies of brain microstructure and pathology.