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[Brugada's syndrome: experience in Cuba in 2001]

Francisco Dorticós Balea1, Margarita Dorantes Sánchez, Jorge Luis Arbaiza Simón

  • 1Servicio de Arritmias y Estimulación Cardíaca, Instituto de Cardiología y Cirugía Cardiovascular Ciudad de La Habana, Cuba. marccard@infomed.sld.cu

Archivos De Cardiologia De Mexico
|November 7, 2002
PubMed

Insights

Brugada syndrome, a genetic heart condition, was studied in 14 Cuban patients. Early diagnosis and implantable cardioverter-defibrillators are key for managing life-threatening arrhythmias and preventing sudden cardiac death.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Genetics

Context:

  • Brugada syndrome is a primary electrical disorder causing sudden cardiac death in individuals with structurally normal hearts.
  • It presents with characteristic ECG abnormalities like ST segment elevation and pseudo right bundle branch block.
  • The syndrome predisposes individuals to life-threatening ventricular arrhythmias.

Purpose:

  • To characterize patients diagnosed with Brugada syndrome in Cuba between 1995 and 2001.
  • To evaluate diagnostic tools and treatment strategies for Brugada syndrome in this cohort.

Summary:

  • Fourteen patients (13 male, 1 female, mean age 42.8) were studied, with 7 symptomatic and 7 asymptomatic.
  • Pharmacological testing with sodium channel blockers proved highly effective (100% positive).
  • Programmed ventricular stimulation induced arrhythmias in 5 patients (3 symptomatic, 2 asymptomatic).
  • Implantable cardioverter-defibrillators were used for all symptomatic patients and inducible asymptomatic cases.
  • A single recurrence of ventricular arrhythmia was noted, with rare use of antiarrhythmic drugs.

Impact:

  • Highlights the diagnostic utility of clinical history, ECG, and pharmacological challenge in Brugada syndrome.
  • Emphasizes the implantable cardioverter-defibrillator as the primary treatment for preventing sudden cardiac death.
  • Suggests that even masked or transient ECG findings warrant consideration for Brugada syndrome diagnosis.

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