[Gel derived bioactive ceramic as bone substitute--an in vivo study]

The paper presents the histopathological and radiological study performed on a series of male, mixed-race rabbits. All rabbits had a 20 x 4 x 4 mm-bone fragment extracted from the radial bone according to a modified technique by Scmitt and Weller. In the right radius bone the bone defect was filled with approximately 0.5 cm3 bioglass S2. In the left rius, which served as control, allogenic bone graft (the size of the defect) collected from the tibia and femur was implanted. Rabbits were sacrificed 3, 6 and 12 weeks after the procedure and histopathological and radiological studies were performed. These studies revealed a heterogeneous increase of new bone regeneration in all three phases of the study. The S2 biomaterial both stimulated and accelerated bone regeneration in the rabbits.