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What can PROTEKT tell us at a local level?
1Department of Microbiology, Kitasato University, Sagamihara, Kanagawa, Japan.
Journal of Chemotherapy (Florence, Italy)
|November 7, 2002
Summary
Antimicrobial resistance surveillance is crucial for guiding treatment. The PROTEKT study highlights significant local variations in resistance patterns for common respiratory pathogens, emphasizing the need for localized data.
Area of Science:
- Infectious Diseases
- Microbiology
- Pharmacology
Background:
- Rising antimicrobial resistance in community-acquired respiratory tract infections (CARTIs) necessitates global surveillance.
- Accurate data is essential for guiding empiric antimicrobial therapy choices.
- The PROTEKT study was initiated to address these surveillance needs.
Purpose of the Study:
- To monitor the global development of antimicrobial resistance in key pathogens.
- To provide timely, internet-disseminated data for local therapeutic decisions.
- To evaluate the efficacy of the ketolide telithromycin against resistant organisms.
Main Methods:
- A longitudinal, global, multicenter surveillance study.
- Monitoring antimicrobial susceptibility patterns of *Streptococcus pneumoniae*, *Streptococcus pyogenes*, and *Haemophilus influenzae*.
- Data dissemination via the internet for clinical guidance.
Main Results:
- Significant variations in antimicrobial susceptibility were observed between geographically close locations in Japan, USA, and Europe.
- Telithromycin demonstrated potent in vitro activity against all tested organisms.
- The first year of PROTEKT yielded valuable insights into resistance prevalence.
Conclusions:
- Local surveillance data is critical due to observed resistance variations.
- Telithromycin shows promise as a new agent for empiric CARTI therapy.
- The PROTEKT study provides essential information for guiding antimicrobial therapy and policy.