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Catecholaminergic polymorphic ventricular tachycardia in a 3-year-old with occult myocarditis
Randall M Bryant1, Sharon P Redfearn, Don Marangi
1University of Florida Pediatric Cardiovascular Center, Jacksonville 32207, USA. rmbryant@ufl.edu
Abstract:
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare clinical entity in children. Occult myocarditis has not been previously implicated as an etiologic agent. A 3-year-old female presents with a presumed breath-holding spell and is found to have ventricular fibrillation requiring DC cardioversion. An invasive electrophysiological study was performed demonstrating the absence of inducible ventricular arrhythmias. Low dose epinephrine confirmed the presence CPVT. Right ventricular endomyocardial biopsies sent for polymerase chain reaction (PCR) analysis demonstrated the presence of adenoviral DNA. The authors hypothesize that occult myocarditis may be the inciting agent for CPVT in children.
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