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Updated: Jul 17, 2026
14:37
High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
Published on: July 6, 2012
Rapid synthesis of a glycosylphosphatidylinositol-based malaria vaccine using automated solid-phase oligosaccharide
Michael C Hewitt1, Daniel A Snyder, Peter H Seeberger
1Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139, USA.
Journal of the American Chemical Society
|November 7, 2002
Abstract:
Described is an automated synthesis of hexasaccharide malarial toxin 1, currently under development as a malaria vaccine candidate. Using a combination of automated solid-phase methods and solution-phase fragment coupling, the target glycosylphosphatidylinositol was assembled in a matter of days, compared with several weeks for a comparable solution-phase synthesis.
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