The neurobehavioural consequences of St. Louis encephalitis infection
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Updated: Sep 28, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Kevin W Greve1, Rebecca J Houston, Donald Adams
1Department of Psychology, University of New Orleans-Lakefront, New Orleans, LA 70148, USA. kgreve@uno.edu
Background:
St. Louis encephalitis (SLE) is a relatively common cause of neurological illness, yet little is known about its cognitive and psychosocial consequences.
Purpose:
To describe the cognitive, emotional, psychophysiological, and psychosocial consequences of SLE infection.
Method:
A comprehensive neuropsychological and psychophysiological evaluation of a high functioning woman 6 weeks and 1 year after acute SLE infection is presented. The focus and course of rehabilitation is also examined.
Results:
The primary cognitive consequences of SLE infection involved attention, working memory, speed of processing, and cognitive efficiency. Depression was also observed. Psychometric testing suggested that these deficits largely resolved after 1 year.
Conclusions:
SLE produces neurocognitive deficits which are reflected in both psychometric and psychophysiologic measures and functional status. Psychometric and vocational improvement were observed over 1 year. However, the normal vocational return came at a significant psychosocial cost. This case emphasizes the importance of a comprehensive neuropsychological evaluation and illustrates the importance of an integrated rehabilitation programme.
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