Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Supersensitivity to dopaminergic agonists induced by haloperidol.

J E Thornburg, K E Moore

    National Institute on Drug Abuse Research Monograph Series
    |November 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Environmental controls on the photosynthesis and respiration of a boreal lichen woodland: a growing season of whole-ecosystem exchange measurements by eddy correlation.

    Oecologia·2017
    Same author

    High follicle density does not decrease sweat gland density in Huacaya alpacas.

    Journal of thermal biology·2014
    Same author

    Rumen-protected methionine supplementation and fibre production in alpacas (Vicugna pacos).

    Journal of animal physiology and animal nutrition·2012
    Same author

    Zonal model of an adaptive mirror.

    Applied optics·2010
    Same author

    Rotationally symmetric construction optics for a waveguide focusing grating.

    Applied optics·2010
    Same author

    Pathophysiologic characteristics of hypovolemic shock.

    The Veterinary clinics of North America. Small animal practice·2001
    Same journal

    History of drug use.

    National Institute on Drug Abuse research monograph series·1976
    Same journal

    Functional taxonomy of drugs.

    National Institute on Drug Abuse research monograph series·1976
    Same journal

    Development of Chronomers tm for narcotic antagonists.

    National Institute on Drug Abuse research monograph series·1976
    Same journal

    Use of synthetic polypeptides in the preparation of biodegradable delivery vehicles for narcotic antagonists.

    National Institute on Drug Abuse research monograph series·1976
    Same journal

    Sustained release of naltrexone from glyceride implants.

    National Institute on Drug Abuse research monograph series·1976
    Same journal

    Long-acting narcotic antagonist complexes.

    National Institute on Drug Abuse research monograph series·1976
    See all related articles

    Chronic haloperidol (a neuroleptic) administration in mice led to withdrawal hyperactivity upon drug removal. This suggests neuroleptic treatment may enhance dopamine receptor sensitivity, impacting behavior.

    Area of Science:

    • Neuropharmacology
    • Behavioral Neuroscience
    • Psychopharmacology

    Background:

    • Neuroleptic medications like haloperidol are used to treat psychosis by blocking dopamine receptors.
    • Understanding the long-term effects of dopamine receptor blockade is crucial for managing treatment side effects.

    Purpose of the Study:

    • To investigate the behavioral consequences of chronic haloperidol and pimozide administration in mice.
    • To examine the development and characteristics of withdrawal hyperactivity following neuroleptic treatment.
    • To explore the role of dopamine receptor sensitivity in neuroleptic-induced behavioral changes.

    Main Methods:

    • Mice were fed diets containing haloperidol or pimozide for varying durations (1-11 days).
    • Locomotor activity was measured before, during, and after drug withdrawal.

    Related Experiment Videos

  • Dose-response curves for dopaminergic agonists (apomorphine, piribedil, L-DOPA, d-amphetamine) were assessed during withdrawal.

    • Main Results:

    • Chronic haloperidol and pimozide reduced locomotor activity; drug removal induced significant withdrawal hyperactivity.
    • Withdrawal hyperactivity was maximal after 6 days of haloperidol treatment and persisted for several days.
    • Dopaminergic agonists showed enhanced effects (motor activity, rearing, gnawing) during withdrawal, indicating increased receptor sensitivity.

    Conclusions:

    • Prolonged blockade of central dopamine receptors by neuroleptics can lead to adaptive changes, such as enhanced receptor sensitivity.
    • This enhanced sensitivity likely underlies the observed withdrawal hyperactivity and altered behavioral responses to dopaminergic agonists.
    • The findings support the hypothesis that neuroleptic treatment induces receptor supersensitivity, contributing to behavioral withdrawal symptoms.