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The changes of cytokeratin 19 during oral carcinogenesis
Minhai Nie1, Li Zhong, Guangming Zeng
1Department of Oral Medicine, Hospital Affiliated to Luzhou Medical College, Luzhou Sichuan 646000, China.
Objective:
To investigate the changes of cytokeratin 19 during oral carcinogenesis.
Methods:
53 specimens including normal oral mucosa, oral epithelial hyperplasia, oral epithelial dysplasia and oral squamous cell carcinoma were investigated by immunohistochemistry, SDS-PAGE and Western blotting.
Results:
CK19 was detectable in suprabasal cell layers in epithelial dysplasia and in oral cancer, especially in poor-differentiated cancerous cells. With the lesions getting worse, the positive rate, the intensity and the constituent ratio of CK19 raised significantly.
Conclusions:
The results suggest that the CK19 expression in suprabasal cell layers of oral mucosa can be used as a marker of diagnosis of oral precancerous lesions and CK19 expression is the initial events during oral carcinogenesis.