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A clinicopathologic and immunohistochemical study of diffuse large B-cell lymphoma
Kun Tao1, Xiongzeng Zhu, Weiling Xu
1Department of Pathology, Cancer Hospital, Fudan University, Shanghai 200032, China.
Zhonghua Bing Li Xue Za Zhi = Chinese Journal of Pathology
|November 7, 2002
Summary
This study analyzed diffuse large B-cell lymphoma (DLBCL) using clinicopathologic and immunohistochemical features. Immunohistochemistry is valuable for DLBCL diagnosis and differential diagnosis, aiding in understanding its aggressive nature.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin lymphoma.
- Accurate diagnosis and subtyping are crucial for effective treatment strategies.
Purpose of the Study:
- To investigate the clinicopathologic and immunohistochemical characteristics of DLBCL.
- To assess the utility of immunohistochemistry in the diagnosis and differential diagnosis of DLBCL.
Main Methods:
- Sixty DLBCL cases were analyzed.
- Immunohistochemical staining was performed for LCA, L26, BLA-36, CD30, and bcl-6 using the EnVision 2-step method.
Main Results:
- The majority of patients (76.7%) were aged 40-70 years.
- Histopathologic morphology was predominantly centroblastic (88.3%).
- Immunohistochemistry revealed high positivity for LCA, L26, and BLA36 (100%), with 95% expressing bcl-6.
Conclusions:
- DLBCL exhibits cytologic variability and is an aggressive lymphoma.
- Pathologic features and immunohistochemistry are practical tools for DLBCL diagnosis.
- Immunohistochemistry aids in diagnosis but does not delineate distinct morphologic subtypes.