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Two pathways to NF-kappaB
Joel L Pomerantz1, David Baltimore
1Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
Molecular Cell
|November 7, 2002
Abstract:
NF-kappaB is a transcription factor that is critical for innate and adaptive immunity. Recently, a noncanonical pathway for NF-kappaB activation has emerged. Four recent papers provide physiological roles for this pathway and expand our understanding of lymphoid development and organogenesis with potential applications in the treatment of autoimmune disease.