Related Experiment Video
Updated: Sep 28, 2026

Rat Burn Model to Study Full-Thickness Cutaneous Thermal Burn and Infection
Published on: August 23, 2022
Comparison of hospital-acquired infection rates in paediatric burn patients
1Institute of Hygiene, Free University Berlin, Germany. Gastmeier.Petra@mh-hannover.de
Insights
Hospital-acquired infections in pediatric burn patients are common. Total burn surface area (TBSA) impacts burn wound infections, but not device-associated infections, guiding targeted surveillance strategies.
Area of Science:
- Pediatric critical care medicine
- Infectious disease epidemiology
- Burn patient management
Background:
- Hospital-acquired infections (HAIs) pose significant risks to vulnerable pediatric burn patients.
- Effective surveillance is crucial for preventing and controlling HAIs in specialized burn units.
Purpose of the Study:
- To identify risk factors for common HAIs in pediatric burn patients.
- To provide evidence-based recommendations for HAI surveillance in burn centers.
Main Methods:
- Prospective cohort study conducted over two years in a pediatric burn center.
- Uni- and multivariate analyses were employed for risk factor identification.
- Data collected on 41 pediatric burn patients with a mean Total Burn Surface Area (TBSA) of 18.9%.
Main Results:
- Overall HAI rate was 59.7 per 1000 patient days.
- Device-associated infection rates: pneumonia (55.2), primary bloodstream infections (8.9), urinary tract infections (41.7) per 1000 device days.
- TBSA was a significant risk factor for burn wound infections, but not for device-associated infections. Urinary catheter use and ventilation duration were risk factors for respective HAIs.
Conclusions:
- Standard HAI surveillance methods, as recommended by the National Nosocomial Infections Surveillance system, are applicable to burn intensive care units.
- TBSA should not be considered for device-associated HAI surveillance but is crucial for stratifying burn wound infection rates.
Abstract:
The objective of the present study was to determine risk factors for development of the most common hospital-acquired infections in paediatric burn patients in order to give recommendations for surveillance. The prospective cohort study in a paediatric burn centre was conducted over a period of two years using uni- and multivariate analysis for risk factor identification. In a group of 41 children with an mean total burn surface area (TBSA) of 18.9% 42 hospital-acquired infections were observed. The overall infection rate was 59.7 nosocomial infections per 1000 patient days, the device-associated nosocomial infection rates per 1000 device days were 55.2 for pneumonia, 8.9 for primary bloodstream infections and 41.7 for urinary tract infections. The incidence density of burn wound infections was 18.5 per 1000 patient days. The percentage of TBSA was a significant risk factor for burn wound infections, but percentage of TBSA was not a risk factor for the device-associated infections. Duration of urinary catheter use and ventilation were identified as risk factors for the corresponding hospital-acquired infection. Surveillance of hospital-acquired infections in burn intensive care units should be performed in the same way as other intensive care unit types, as recommended by the National Nosocomial Infections Surveillance system, without consideration of the percentage of TBSA. In addition, burn wound infections should be recorded using the percentage of TBSA for stratification of burn wound infection rates.
Related Concept Videos
Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Burn Injuries
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Pneumonia I: Introduction
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...
