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Chemical modification of reveromycin A and its biological activities
Takeshi Shimizu1, Takeo Usui, Kiyotaka Machida
1Synthetic Organic Chemistry Laboratory, RIKEN (The Institute of Physical and Chemical Research), Wako, Saitama, Japan. tshimizu@postman.riken.go.jp
Bioorganic & Medicinal Chemistry Letters
|November 7, 2002
Abstract:
Various derivatives of reveromycin A, a novel inhibitor of eukaryotic cell growth, were prepared and their inhibitory effects on both isoleucyl-tRNA synthetase activity and in vitro protein synthesis, and activities on the morphological reversion of src(ts)-NRK cells were assayed. The C5 hydroxyl group and C24 carboxyl group are particularly important for these activities.