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Novel 2,5-dideoxystreptamine derivatives targeting the ribosomal decoding site RNA
Dionisios Vourloumis1, Masayuki Takahashi, Geoffrey C Winters
1Department of Medicinal Chemistry, Anadys Pharmaceuticals, Inc., San Diego, CA 92121, USA. dvourloumis@anadyspharma.com
Bioorganic & Medicinal Chemistry Letters
|November 7, 2002
Abstract:
The ribosomal decoding site is the target of aminoglycoside antibiotics that specifically recognize an internal loop RNA structure. We synthesized RNA-targeted 2,5-dideoxystreptamine-4-amides in which a sugar moiety in natural aminoglycosides is replaced by heterocycles.