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5-HT1A receptor antagonist administration decreases cell proliferation in the dentate gyrus
Jason J Radley1, Barry L Jacobs
1Department of Psychology, Princeton University, Princeton, NJ 08544, USA. jason.radley@mssm.edu
Brain Research
|November 7, 2002
Abstract:
This study investigated the action of 5-HT(1A) receptor antagonists on cell proliferation in the dentate gyrus of adult rats. Three antagonists (NAN-190, p-MPPI and WAY-100635) all produced a statistically significant approximately 30% reduction in the number of BrdU-immunoreactive cells in the dentate gyrus. This suggests that 5-HT(1A) receptor activity is important during naturally occurring cell proliferation in the dentate gyrus, and perhaps neurogenesis, and is one of the many factors involved in its regulation.