Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Beta-blocker therapy for dynamic left-ventricular outflow tract obstruction.

Faisal Al-Nasser1, Alison Duncan, Rakesh Sharma

  • 1Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, UK.

International Journal of Cardiology
|November 7, 2002
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Racial and Ethnic Variations in a Multi-Channel Psychiatric Emergency Services Program.

Community mental health journal·2026
Same author

Five-Year Outcomes of Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation: Results From the Tendyne Expanded Clinical Study.

ESC heart failure·2026
Same author

A Crisis Care Continuum for Children and Adolescents: The Boston Medical Center Model.

Child and adolescent psychiatric clinics of North America·2026
Same author

Correction: Bridging crisis and care: exploring the role of behavioral health professionals in a police co-response model.

Health & justice·2026
Same author

Self-expanding versus balloon-expandable valves in patients undergoing urgent or emergent TAVI.

International journal of cardiology·2026
Same author

Evolution of Right Ventricular Function and Pulmonary Artery Coupling After Transapical Transcatheter Mitral Valve Replacement.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2026

Beta-blockade therapy significantly improved symptoms and ventricular physiology in elderly patients with dynamic left-ventricular outflow tract obstruction (DLVOTO). This approach may be beneficial for selected patients identified via stress echocardiography.

Area of Science:

  • Cardiology
  • Geriatrics
  • Pharmacology

Background:

  • Dynamic left-ventricular outflow tract obstruction (DLVOTO) can cause breathlessness in elderly patients.
  • Identifying the cause of symptoms is crucial for effective treatment in this demographic.

Purpose of the Study:

  • To investigate the effects of beta-blockade on ventricular physiology and symptoms in elderly patients with DLVOTO.
  • To assess the therapeutic potential of beta-blockers for DLVOTO.

Main Methods:

  • A pilot study involving 15 elderly patients (mean age 76) with exercise intolerance and DLVOTO.
  • Patients received oral atenolol; 11 tolerated the medication.
  • Evaluated changes in rate pressure product, left ventricular outflow tract velocity, and New York Heart Association (NYHA) class.

Related Experiment Videos

Main Results:

  • Tolerable atenolol therapy reduced rate pressure product by 23% (P=0.028) and LV outflow tract velocity by 23% (P=0.001).
  • Significant symptom improvement was observed, with mean NYHA class decreasing from 2.8 to 1.5 (P<0.0001).

Conclusions:

  • Beta-blockade is a potentially beneficial treatment for selected elderly patients with DLVOTO.
  • Stress echocardiography can identify patients who may benefit from this therapeutic approach.