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Trypanocidal terpenoids from Laurus nobilis L
Nahoko Uchiyama1, Keiji Matsunaga, Fumiyuki Kiuchi
1Graduate School of Pharmaceutical Sciences, Kyoto University, Japan.
Chemical & Pharmaceutical Bulletin
|November 7, 2002
Abstract:
Trypanocidal constituents of dried leaves of Laurus nobilis L. (Lauraceae) were examined. Activity-guided fractionation of the methanol extract resulted in the isolation of two guaianolides, dehydrocostus lactone (1) and zaluzanin D (2), and a new p-menthane hydroperoxide, (1R,4S)-1-hydroperoxy-p-menth-2-en-8-ol acetate (3). The minimum lethal concentrations of these compounds against epimastigotes of Trypanosoma cruzi were 6.3, 2.5, and 1.4 microM, respectively.