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Related Experiment Videos

Increased urinary hydrogen peroxide levels caused by coffee drinking.

Kazuyuki Hiramoto1, Tomoko Kida, Kiyomi Kikugawa

  • 1School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan.

Biological & Pharmaceutical Bulletin
|November 7, 2002
PubMed
Summary

Coffee consumption significantly elevates urinary hydrogen peroxide levels in healthy individuals. This increase is primarily attributed to 1,2,4-benzenetriol excreted in urine following coffee intake.

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Area of Science:

  • Biochemistry
  • Human Physiology
  • Nutritional Science

Background:

  • Previous studies indicated coffee's impact on urinary hydrogen peroxide.
  • The specific mechanisms and extent in different populations required further investigation.

Purpose of the Study:

  • To re-examine the effect of coffee consumption on urinary hydrogen peroxide levels in healthy Japanese subjects.
  • To identify the primary metabolite responsible for increased hydrogen peroxide.

Main Methods:

  • Quantification of hydrogen peroxide generated by coffee in vitro.
  • Measurement of urinary hydrogen peroxide levels in subjects before and after coffee consumption.
  • Analysis of urine samples for the presence of 1,2,4-benzenetriol.

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Main Results:

  • Commercially available Japanese coffee generated significant hydrogen peroxide in vitro.
  • Urinary hydrogen peroxide levels increased 3-10 fold 1-2 hours after coffee consumption.
  • 1,2,4-benzenetriol was identified as the major contributor to increased hydrogen peroxide.

Conclusions:

  • Coffee consumption leads to a marked increase in urinary hydrogen peroxide.
  • 1,2,4-benzenetriol is the principal metabolite responsible for this effect.
  • A portion of the hydrogen peroxide generated may be retained or metabolized within the body.