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Gardner's syndrome - a case report.

M Payne1, J A Anderson, J Cook

  • 1Dental Radiology and Assessment and Casualty, Charles Clifford Dental Hospital, Wellesley Road, Sheffield S10 2SZ. martin.payne@sth.nhs.uk

British Dental Journal
|November 7, 2002
PubMed
Summary

Gardner's syndrome links colon polyps with skin cysts and jaw tumors. Early dental detection of these signs can save lives by enabling timely cancer treatment.

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Area of Science:

  • Genetics and Medicine
  • Oncology
  • Dentistry

Background:

  • Gardner's syndrome is an inherited condition characterized by familial adenomatous polyposis coli (FAP).
  • It involves multiple colonic polyps, sebaceous cysts, and jaw osteomas.
  • This syndrome has significant implications for early diagnosis and patient management.

Observation:

  • The colonic polyps in Gardner's syndrome typically become malignant by the fourth decade.
  • Extra-intestinal manifestations, such as jaw osteomas and sebaceous cysts, can appear before intestinal polyps.
  • Dental professionals may be the first to observe key diagnostic signs.

Findings:

  • Early identification of multiple jaw osteomas and/or sebaceous cysts is crucial.
  • These findings can prompt further investigation into potential gastrointestinal malignancy.
  • Diagnosis has implications for affected individuals and their family members.

Implications:

  • Prompt diagnosis and treatment can be life-saving.
  • Dentists play a vital role in the early detection of Gardner's syndrome.
  • Genetic counseling and screening are important for affected families.

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