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Updated: Sep 28, 2026

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma
05:22

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma

Published on: February 13, 2026

[Antithrombin III, protein C and thrombin/antithrombin III complexes (TAT) in patients suffering from chronic

Jacek J Lewandowski1, Marzenna Galar, Katarzyna Mazgajska-Barczyk

  • 1Oddział Chirurgii Ogólnej Wojewódzkiego Szpitala Zespolonego w Białymstoku.

Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego
|November 8, 2002
PubMed

Insights

Both laparoscopic and traditional cholecystectomy increase thrombin generation, posing similar risks for thrombo-embolic complications after gallbladder surgery.

Area of Science:

  • General Surgery
  • Vascular Surgery
  • Gastrointestinal Surgery

Context:

  • Cholelithiasis (gallstones) is commonly treated with surgery.
  • Laparoscopic cholecystectomy has largely replaced traditional open surgery.
  • Evaluating surgical impacts on hemostasis is crucial for patient safety.

Purpose:

  • To compare hemostasis and coagulation changes after laparoscopic versus classical cholecystectomy.
  • To assess the risk of thrombo-embolic complications associated with both surgical methods.

Summary:

  • A study involving 48 patients with chronic cholelithiasis (29 laparoscopic, 19 classical) evaluated hemostasis.
  • Both surgical approaches resulted in a comparable increase in thrombin generation within the vascular bed.
  • This indicates that both laparoscopic and classical cholecystectomy are risk factors for thrombo-embolic events.

Impact:

  • Findings suggest that while laparoscopic surgery is less invasive, it carries similar hemostatic risks to open surgery.
  • Highlights the need for vigilance regarding thrombo-embolic complications in all forms of cholecystectomy.
  • Informs clinical practice regarding perioperative management and risk assessment for patients undergoing gallbladder removal.

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