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Updated: Aug 9, 2026
Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy
Published on: April 29, 2014
Metastatic renal cell carcinoma involving the rectum
Mário A Rosito1, Daniel C Damin, Anderson R Lazzaron
1Departments of Coloproctological Surgery, Pathology, and Oncology, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Background And Aims:
Metastatic spread of a distant tumor to the rectum is extremely rare. To our knowledge, there have been no published reports of hematogenic metastasis from a renal cell carcinoma to the rectum.
Patients And Methods:
A patient with a renal cell carcinoma was initially treated by a radical right nephrectomy.
Results:
Nine months after the surgery he started to have multiple episodes of hematochezia. Colonoscopy showed a nodular lesion located in the distal rectum, and biopsy revealed an undifferentiated carcinoma. The patient then underwent abdominoperineal resection of the rectum, and histological examination showed metastatic renal clear cell carcinoma.
Conclusion:
This case represents an exceedingly rare condition, which has never been reported before.
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