Related Experiment Videos
The activity of superoxide dismutase in hydroxyurea-treated E beta thalassemia
H Ajanta1, Sheela Chakraborty, De Madhusnata
1Thalassaemia Counselling Department, Vivekananda Institute of Medical Science, Ramakrishna Mission Seva Pratisthan, Calcutta, India.
Aim:
To study the activity of superoxide dismutase (SOD) and the level of fetal hemoglobin (HbF) in hydroxyurea (HU)-treated E beta thalassaemia.
Methods:
We have measured SOD level, HbF, mean corpuscular volume (MCV), packed cell volume (PCV) and hemoglobin (Hb) of E beta thalassaemia treated with HU (dose 30 mg/kg/day) for consecutive 90 days.
Result:
The increase of HbF synthesis without increase of Hb was observed in HU-treated patients.
Conclusion:
The decreased SOD level in long term and low dose of HU therapy in E beta thalassaemia may have some role to inhibit superoxide radical of erythrocyte. HU may act as inhibitor for oxidative damage of red cell in E beta thalassaemia.