Related Experiment Videos
Laboratory evaluation of hypercoagulability with venous or arterial thrombosis
Elizabeth M Van Cott1, Michael Laposata, Martin H Prins
1Department of Pathology, Massachusetts General Hospital, Boston 02114, USA. evancott@partners.org
Insights
This study offers 17 expert-backed recommendations for hypercoagulation testing in patients experiencing venous, arterial, or neurovascular thrombosis. These guidelines aid in selecting appropriate tests for thrombotic conditions.
Area of Science:
- Medical Science
- Hematology
- Clinical Practice Guidelines
Background:
- Hypercoagulation, a state of increased blood clotting, is a significant risk factor for various thrombotic events.
- Accurate hypercoagulation testing is crucial for diagnosing and managing patients with venous, arterial, or neurovascular thrombosis.
- Existing guidelines for hypercoagulation testing require updates based on current literature and expert consensus.
Purpose of the Study:
- To develop evidence-based recommendations for hypercoagulation testing in patients with venous, arterial, or neurovascular thrombosis.
- To establish a consensus among experts on the appropriate selection of hypercoagulation tests.
- To provide a comprehensive guide for clinicians managing thrombotic disorders.
Main Methods:
- Extensive literature review and analysis of current practices in hypercoagulation testing.
- Development of a preliminary manuscript with recommendations by the authors.
- Circulation of the draft manuscript to 30 expert participants prior to a consensus conference.
- Presentation and discussion of the manuscript and recommendations at the consensus conference.
- Acceptance of recommendations based on consensus among 28 attending experts.
Main Results:
- The study resulted in 17 distinct recommendations for hypercoagulation testing.
- Evidence supporting the selection of specific tests for hypercoagulation is analyzed and cited.
- Consensus was reached on the majority of recommendations presented.
- Areas where consensus could not be achieved are also identified and discussed.
Conclusions:
- The developed recommendations provide a standardized approach to hypercoagulation testing for thrombotic conditions.
- These guidelines aim to improve diagnostic accuracy and patient management in cases of venous, arterial, or neurovascular thrombosis.
- The consensus-driven recommendations reflect the collective expertise in the field of hypercoagulation and thrombosis.
Objective:
To provide recommendations for hypercoagulation testing for patients with venous, arterial, or neurovascular thrombosis, as reflected in the medical literature and the consensus opinion of recognized experts in the field.
Data Sources, Extraction, And Synthesis:
The authors extensively examined the literature and current practices, and prepared a draft manuscript with preliminary recommendations. The draft manuscript was circulated to each of the expert participants (n = 30) in the consensus conference prior to the convening of the conference. The manuscript and recommendations were then presented at the conference for discussion. Recommendations were accepted if a consensus of the 28 experts attending the conference was reached. The discussions were also used to revise the manuscript into its final form.
Conclusions:
The resulting article provides 17 recommendations for hypercoagulation testing in the setting of venous, arterial, or neurovascular thrombosis. The supporting evidence for test selection is analyzed and cited, and consensus recommendations for test selection are presented. Issues for which a consensus was not reached at the conference are also discussed.